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Diclofenac Sodium is the salt form of Diclofenac, an active metabolite of the said Aceclofenac (sc - 217557). Hydrolysis of Aceclofenac, an inhibitor of interleukin - 1b - induced prostaglandin e2 production with no inhibitory activity against COX (Cyclooxy Genase), generates Diclofenac, which inhibits both cox-1 and cox-2 oxidation of Diclofenac produces the metabolite H-Hydroxy. Diclofenac demonstrates specific inhibition of Cox-2. Inhibition of cox by Diclofenac and h-hydroxy diclofenac suppress Protaglandin e2 synthesis, producing anti inflammatory and analgesic effects. Diclofenac is also shown to stabilize the native Tetrameric conformation of Transthyretin (TTR) fibrils, preventing the formation of insoluble Amyloidogenic TTR deposits.
It is available in different salts such as :
|Shelf Life||1 Year|
|Storage||Cool & Dry Place|