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Diphenhydramine HCL IS a first-generation antihistamine mainly used to treat allergies. like most first generation antihistamines, the drug also has a powerful hypnotic effect, and for this reason is often used as a nonprescription sleep aid and a mild anxiolytic. The drug also acts as antiemetic properties which make it useful in treating the nausea that occurs in motion sickness. It is used to treat a number of conditions including allergic symptoms and itchiness, the common cold, insomnia, motion sickness, and extrapyramidal symptoms. Despite being one of the oldest antihistamines, it is more effective than even some of the latest prescription drugs. Consequently, it is frequently used when an allergic reaction requires fast, effective reversal of the often dangerous effects of a massive histamine release. It has sedative properties and is widely used in nonprescription sleep aids. The drug is an ingredient in several products sold as sleep aids, either alone or in combination with other ingredients such as paracetamol. There are also topical formulations of diphenhydramine available, including creams, lotions, gels, and sprays. They are used to relieve itching, and have the advantage of causing much less systemic effect (i.e. drowsiness) than oral forms. As diphenhydramine is extensively metabolized by the liver, caution should be exercised when giving the drug to individuals with hepatic impairment.
Diphenhydramine reduces itching that is associated with an allergic reaction, making it a popular choice for treatment of the symptoms of allergic rhinitis, hives, motion sickness, and insect bites and stings.
Diphenhydramine HCL is a white crystalline powder, which is very soluble in water, freely soluble in alcohol.
|Melting Point||168-172 °C|
|Boiling Point||343.7 °C at 760 mmHg|
|Flash Point||101.5 °C|