Latest Products http://www.umabrothers.in Latest Products Thu, 23 Jan 2020 05:45:09 +0530 en-us http://www.umabrothers.in Curcumin 95% http://www.umabrothers.in/curcumin-95.htm http://www.umabrothers.in/curcumin-95.htm Fri, 10 Jan 2020 00:00:00 +0530 Curcumin is a diarylheptanoid. About two centuries ago, isolation of a “yellow coloring-matter” from the rhizomes of curcuma longa (turmeric) & was named curcumin.  Turmeric's other two curcuminoids are desmethoxycurcumin and bis-desmethoxy- curcumin. The curcuminoids are natural phenols that are responsible for the yellow color of turmeric. Curcumin can exist in several tautomeric forms, including a 1, 3-diketo form and two equivalent enol forms. The enol form is more energetically stable in the solid phase and in organic solvents, while in water the 1, 3-diketo dominates. Curcumin can be used for boron quantification in the curcumin method. It reacts with boric acid to form a red-color compound, rosocyanine. Curcumin is a bright-yellow color powder and may be used as a food coloring. Curcumin is powerful anti-inflammatory effects and is a very strong antioxidant. Combat cancer stem cells and enhance heart health and inhibit the formation of ldl (bad) cholesterol.It Is Orange Crystalline Powder With Its Melting Point Of 183 °C. It Is Slightly Soluble In Hot Water Atenolol http://www.umabrothers.in/atenolol.htm http://www.umabrothers.in/atenolol.htm Fri, 10 Jan 2020 00:00:00 +0530 Atenolol is a cardioselective beta-1 adrenergic blocker possessing properties and potency similar to propranolol, but without a negative inotropic effect.Atenolol is a synthetic isopropylamino-propanol derivative used as an antihypertensive, hypotensive and antiarrhythmic atenolol acts as a peripheral, cardioselective beta blocker specific for beta-1 adrenergic receptors, without intrinsic sympathomimetic effects. It reduces exercise heart rates and delays atrioventricular conduction, with overall oxygenrequirements decreasing.Atenolol Is A white To Off-White Powder. It Is Soluble In Water (25 Mm), Dmso (18 Mg/Ml), Ethanol (3.4 Mg/Ml), Methanol (50 Mg/Ml), And Water (26.5 Mg/Ml At 37 °C) With Melting Range Of 146°C - 148°C. Betamethasone http://www.umabrothers.in/betamethasone.htm http://www.umabrothers.in/betamethasone.htm Fri, 10 Jan 2020 00:00:00 +0530 Betamethasone is a corticosteroid. The mechanism of action of betamethasone is as a corticosteroid hormone receptor agonist. Betamethasone is a synthetic glucocorticoid with metabolic, immunosuppressive and anti-inflammatory activities. Betamethasone binds to specific intracellular glucocorticoid receptors and subsequently binds to dna to modify gene expression. The synthesis of certain anti-inflammatory proteins is induced while the synthesis of certain inflammatory mediators is inhibited. As a result, there is an overall reduction in chronic inflammation and autoimmune reactions.A glucocorticoid given orally, parenterally, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated. Its lack of mineralocorticoid properties makes betamethasone particularly suitable for treating cerebral edema and congenital adrenal hyperplasia.Betamethasone Is A White To Off-White Solid. It Is Soluble In Methanol With Melting Range Of 231°C To 234°C.Synonyms(8s,9r,10s,11s,13s,14s,16s,17r)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahy drocyclopenta [a]phenanthren-3-one Bicalutamide http://www.umabrothers.in/bicalutamide.htm http://www.umabrothers.in/bicalutamide.htm Fri, 10 Jan 2020 00:00:00 +0530 Bicalutamide is a synthetic, nonsteroidal antiandrogen. Bicalutamide competitively binds to cytosolic androgen receptors in target tissues, thereby inhibiting the receptor binding of androgens. This agent does not bind to most mutated forms of androgen receptors.Bicalutamide is an oral non-steroidal anti-androgen for prostate cancer. It binds to the androgen receptor.Bicalutamide Is A Off-White Crystalline Solid. It Is Slightly Soluble In Chloroform And Absolute Ethanol; Sparingly Soluble In Methanol; Soluble In Acetone And Tetrahydrofuan Practically Insoluble In Water At 37 Deg C (5 Mg/1000 Ml) With Melting Range Of 191°C To 193°C . Bimatoprost http://www.umabrothers.in/bimatoprost.htm http://www.umabrothers.in/bimatoprost.htm Fri, 10 Jan 2020 00:00:00 +0530 Bimatoprost is a cloprostenol-derived amide that is used as an antihypertensive agent in the treatment of open-angle glaucoma and ocular hypertension.Bimatoprost is a prostaglandin analog. The chemical classification of bimatoprost is prostaglandins.Bimatoprost is a white crystalline solid. It is slightly soluble in water with melting range of 66°c to 68°c. Calamine http://www.umabrothers.in/calamine.htm http://www.umabrothers.in/calamine.htm Fri, 10 Jan 2020 00:00:00 +0530 We are offering calamine is either a mixture of zinc oxide (zno) with about 0.5% ferric oxide (fe2o3) or a zinc carbonate compound. It is the main ingredient in calamine lotion and is used as an anti-pruritic (anti-itching agent) to treat conditions such as sunburn, rashes, poison ivy, poison oak, chickenpox, and insect bites and stings. It is also used as a mild antiseptic to prevent infections that can be caused by scratching the affected area, and an astringent to dry weeping or oozing blisters and acne abscesses.Calamine is a Pink, Odorless, Practically Tasteless, fine Powder. It is Insoluble in Water, Practically Completely Soluble in Mineral Acids with Melting Point of 1975°C. Citicoline Sodium http://www.umabrothers.in/citicoline-sodium.htm http://www.umabrothers.in/citicoline-sodium.htm Tue, 14 Jan 2020 00:00:00 +0530 Citicoline is A Nutritional Supplement And Source Of choline and Cytidine With Potential Neuroprotective And Nootropic Activity. citicoline, Also Known As cytidine-5-Diphosphocholine Orcdp-Choline, Is Hydrolyzed Into Cytidine and choline in The Intestine. Following Absorption, Both cytidine And choline are Dispersed, Utilized In Various Biosynthesis Pathways, And Cross The Blood-Brain Barrier For Resynthesis Into citicoline in The Brain Which Is The Rate-Limiting Product In Synthesis Ofphosphatidylcholine.  This Agent Also Increasesacetylcholine (Ach), norepinephrine (NE) And Dopamine levels In The Central Nervous System (CNS). In Addition, Citicoline is Involved In The Preservation Of Sphingomyelin And Cardiolipin And The Restoration Of Na+/K+-Atpase Activity. citicoline also Increases Glutathione synthesis And glutathione reductase Activity, And Exerts Antiapoptotic Effects.Citicoline Is A White Solid Powder. It Is Soluble In Water With Melting Range Of 259°C TO 268°C. Dextromethorphan Hydrobromide http://www.umabrothers.in/dextromethorphan-hydrobromide.htm http://www.umabrothers.in/dextromethorphan-hydrobromide.htm Fri, 10 Jan 2020 00:00:00 +0530 Methyl analog of dextrorphan that shows high affinity binding to several regions of the brain, including the medullary cough center.this compound is an nmda receptor antagonist (receptors, n-methyl-d-aspartate) and acts as a non-competitive channel blocker.Dextromethorphan hydrobromide is one of the widely used antitussives, and is also used to study the involvement of glutamate receptors in neurotoxicity.Dextromethorphan Hydrobromide Is A White Solid Powder. It Is Soluble In Chloroform And Methanol With Melting Range Of 116°C TO 119°C. Erythromycin http://www.umabrothers.in/erythromycin.htm http://www.umabrothers.in/erythromycin.htm Fri, 10 Jan 2020 00:00:00 +0530 Erythromycin is a macrolide and macrolide antimicrobial. The physiologic effect of erythromycin is by means of decreased sebaceous gland activity. The chemical classification oferythromycin is macrolides. A bacteriostatic antibiotic macrolide produced by streptomyces erythreus. Erythromycin a is considered its major active component. In sensitive organisms, it inhibits protein synthesis by binding to 50s ribosomal subunits. This binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins.Erythromycin is a broad-spectrum, macrolide antibiotic with antibacterial activity. Erythromycin diffuses through the bacterial cell membrane and reversibly binds to the 50s subunit of the bacterial ribosome. This prevents bacterial protein synthesis. Erythromycin may be bacteriostatic or bactericidal in action, depending on the concentration of the drug at the site of infection and the susceptibility of the organism involved.Erythromycin Is White To Off White Crystalline Powder. It Is Soluble In 2 M Hcl (50 Mg/Ml), Ethanol, Water (50 Mg/Ml), Methanol, And Chloroform With Melting Range Of 135°C TO 140°C.Synonyms : (3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-[(2S,3R,4S,6R)-4-(Dimethylamino)-3-Hydroxy-6-Methyloxan-2-YL]OXY-14-Ethyl-7,12,13-Trihydroxy-4-[(2R,4R,5S,6S)-5-Hydroxy-4-Methoxy-4,6-Dimethyloxan-2-YL]OXY-3,5,7,9,11,13-Hexamethyl-Oxacyclotetradecane-2,10-Dione Ferrous Fumarate Powder http://www.umabrothers.in/ferrous-fumarate-powder.htm http://www.umabrothers.in/ferrous-fumarate-powder.htm Fri, 10 Jan 2020 00:00:00 +0530 It Is Reddish Brown Fine Powder, Odorless, Slightly, Salt Taste Of USP/BP/EP/IP STANDARDS.Ferrous Fumarate Contains Not Less Than 101.0 Percent Of C4h2feo4, Calculated On The Dried Basis.Function & Usage : Ferrous Fumarate Is A Form Of The Mineral Iron. Iron Is Important For Many Functions In The Body, Especially For The Transport Of Oxygen In The Blood. Ferrous Fumarate Is Used As Dietary Supplement And To Prevent And To Treat Iron Defeciencies And Iron Deficiency Anemia. We Provide A Wide Array Of  Ferrous Fumarate That Is Formulated Using Premium Quality Chemicals. Offered At Industry Leading Prices, Our Range Of Ferrous Fumarate Is Highly Effective And Can Be Delivered Manufactured In Customized Specifications And Mesh Size As Desired By Our Clients. We Are Offering This Product 25 Kg Per Bag Or Drum Packing And 1 Fcl Of 20 Feet Contains 18 Tons Ferrous Fumarate In 25 Kg Bags. Sodium Starch Glycolate http://www.umabrothers.in/sodium-starch-glycolate.htm http://www.umabrothers.in/sodium-starch-glycolate.htm Tue, 14 Jan 2020 00:00:00 +0530 Sodium Starch Glycolate (CAS No. 9063 – 38 – 1) Is The Sodium Salt Of A Carboxy Methyl Ether Of Starch. The Molecular Weight Is Typically 500000 – 11000000. It Is Available In Both The Form That Is Processed From Maize And Processed From Potato.Very Fine White Or Off White Free Flowing Powder, Odourless Or Almost Odourless Practically Insoluble In Water, Insoluble In Most Prganic Solvents.  It Consists Of Oval Or Spherical Granules 30 – 100 Nm In Diameter With Some Less Spherical Granules Ranging From 10-35 Ium In Diameter.Applications : Sodium Starch Glycolate Is Widely Used In Oral Pharmaceuticals As A Disintegrant In Capsule And Tablet Formulations. It Is Recommended To Use In Tablets Prepared By Either Direct –COMPRESSION Or Wet Granulation Processes. The Recommended Concentration In A Formulation Is 2 – 8 % With The Optimum Concentration About 4% Although In Many Cases 2% Insufficient. Disintegration Occurs By Rapid Uptake Of Water Followed By Rapid And Enormous Swelling. The Disintegrant Efficiency Of Sodium Starch Glycolate Is Unimpaired In The Presence Of Hydrophobic Excipients, Such As Lubricants Unlike Many Other Disintegrants. Increasing The Tablet Compression Pressure Also Appears To Have No Effect On Disintegration Time. Sodium Starch Glycolate Has Also Been Investigated For Use As A Suspending Vehicle Stability And Storage Conditions : Tablets Prepared With Sodium Starch Glycolate Have Good Storage Properties. Sodium Starch Glycolate Is Stable And Should Be Stored In A Well –CLOSED Container To Protect It From Wide Variations In Humidityemperature That May Cause Caking. The Physical Properties Of Sodium Starch Glycolate Remain Unchanged For Upto 4 Yrs If Stored At Moderate Temperature And Humidity.Packing: It Is Available In Export Worthy Bag Or Drum Packing As Per Our Customers Choice Garcinia Cambogia Extract 50% & 60% http://www.umabrothers.in/garcinia-cambogia-extract-50-60.htm http://www.umabrothers.in/garcinia-cambogia-extract-50-60.htm Fri, 10 Jan 2020 00:00:00 +0530 Introduction: Garcinia Cambogia, Is A Small, Sweet, Exotic Fruit Native To South India And South East Asia. Garcinia Has Garnered A Lot Of Attention Of Late As A Popular Natural Weight Loss Acid. The Reason Is That The Rind Of This Pumpkin Like Fruit Is Rich In A Substance Called Hydroxyl Citric Acid/Hca, A Principle Extract Of Garcinia Cambogia.Garcinia Cambogia, A Tropical Fruit Also Known As The Malabar Tamarind, Is A Popular weight-Loss Supplement. People Say It Blocks Your Body's Ability To Make Fat And It Puts The Brakes On Your Appetite. It Could Help Keep blood Sugar and cholesterol Levels in Check, Too.The Active Ingredient In The Fruit's Rind, hydroxycitric Acid, Or Hca, Has Boosted Fat-Burning And Cut Back Appetite In Studies. It Appears To Block An Enzyme Called Citrate Lyase, Which Your Body Uses To Make Fat. It Also Raises Levels Of The brain chemical Serotonin, Which May Make You Feel Less hungry.Garcinia Is A Source For A Revolutionary Natural Diet Ingredient Which Is Currently A Rage In America, Japan, Europe, And Other Western Countries.Pytochemistry: The Plant Contains Acids Tartaric, Citric And Phosphoric. The Latex Of Garcinia Cambogia Contains Two Polyisoprenylated Benzophenone Derivative, Camboginol (I) And Cambogin (II)Chemistry: The Major Phyto Constituent In Garcinia Cambogia Is Hydrocycitric Acid. This Principal Acid Has Been Found To Suppress The Fatty Aid Synthesis, Lipogenesis, Food Intake, And Promotes Glycogenesis, Glyconeogenesis And Induced Weight Loss.Garcinia Can Be Taken By Practically Everyone, Regardless Of Age And Gender. Garcinia Can Be Taken For The Following Reasons.Helps Reduce Body’s Ability, Lowers Body Weight Through Appetite Control, Lowers Serum Triglycerides, Creates A Process In The Body Called Thermogenesis, Helps With Cattarhal Conditions Of The Throat, Urinary System And Uterus Etc.Better Studies Are Needed To Find Out If Hca Really Helps People Lose A Lot Of Weight And Keep It Off.We Are Offering Garcinia Cambogia Of Different Concentration As Well As Soluble And Non Soluble Salts. Also Offering Tailor Made Specifications To Our Customers As They Require. We Offer In Export Worthy Packing Of 25 Kg And 50 Kg Bags & Hdpe Drums.Garcinia Cabogia Extract 50% & 60% (ALSO As Per Our Customer Requirements) PEG-40 Hydrogenated Castor Oil http://www.umabrothers.in/peg-40-hydrogenated-castor-oil.htm http://www.umabrothers.in/peg-40-hydrogenated-castor-oil.htm Fri, 10 Jan 2020 00:00:00 +0530 Peg-40 Hydrogenated Castor Oil Is A Polyethylene Glycol Derivative Of Castor Oil. It Is In Semi-Solid Or Liquid Form. This Vegetable-Based Solubilizer Also Can Be Used As A Surfactant & Cleanser In Cosmetic Production. This Can Be Used As An Emulsifier In Aqueous Finished Products Containing Large Water Phase. Peg-40 Hydrogenated Castor Oil Is Yellow Colour With Mild Odour. It Is Also Used As Solubilizing Agent Or Emulsifier In Cosmetic Formulations Like Sprays, Serums And Lotions & Oil Free Creams. It Is Mixed In Oils As It Has Very Strong Solubilizing Properties. Peg 40 Is Total Free From Any Animal Source As It Is Made From Vegetable Based Materials. As Much As To Our Knowledge, There Are No Hazards Connected With Peg 40 While Preparing Products Or Formulations From It. Precautions To Be Taken When Wound Or Scratches Are There On The Skin.This Is Multifunctional Agent Can Be Used As Emulsifier, Surfactant And Solubilizer. It Can Be Also Used As Foam Booster & Solubilizer Of Extract, Perfumes And Vitamins.Applications: Universally Applicable, Especially In Liquid Soaps, Lotions, Body Washes, Shower Gels, Hair Shampoos, Facial Cleansers, Bubble Baths, Decorative Cosmetics.This Is Available In Export Worthy Packing Of 50 Kg/200 Kg/250 Kg Carboys Or Barrels. We Can Also Offer Our Customers Tailor Made Specifications Of This Product. Ketorolac Tromethamine http://www.umabrothers.in/ketorolac-tromethamine.htm http://www.umabrothers.in/ketorolac-tromethamine.htm Fri, 10 Jan 2020 00:00:00 +0530 Ketorolac Tromethamine Is A Pyrrolizine Carboxylic Acid Derivative Structurally Related To Indomethacin. It Is A Non-Steroidal Anti-Inflammatory Agent Used For Analgesia For Postoperative Pain And Inhibits Cyclooxygenase Activity.Ketorolac Tromethamine is The tromethamine salt Of ketorolac, A Synthetic Pyrrolizine Carboxylic Acid derivative With Anti-Inflammatory, Analgesic & Antipyretic Properties.Ketorolac Tromethamine, A Non-Selective Inhibitor Of The Cyclooxygenases (COX), Inhibits Both Cox-1 & Cox-2 Enzymes. This Agent Exerts Its Anti-Inflammatory Effect By Preventing Conversion Of arachidonic Acid to Prostaglandins At Inflammation Site Mediated Through Inhibition Of Cox-2, Which Is Undetec- Table In Most Tissues But Is Up-Regulated At The Inflammation Sites. Since Cox-1 Is Expressed Virtually In All Tissues, Inhibition Of Cox-1 Enzyme By This Agent Prevents Normal State Production Of Prostaglandins, Which Plays Housekeeping Roles In The Protection Of The Gastrointestinal Tract, Regulating Renal Blood Flow, And Functioning In Platelet Aggregation. As A Result, Inhibition Of Cox-1 Is Usually Associated With Adverse Effects Such As Gastrointestinal Toxicity And Nephrotoxicity.Ketorolac Tromethamine is Off-white to Pale Yellow Solid. It is Soluble in Ethanol (~7 Mg/ml), Dmf (~50 Mg/ml), Dmso (~7 Mg/ml), Water (15 Mg/ml), and Methanol with Melting Range of 160°C to 162°C. Latanoprost http://www.umabrothers.in/latanoprost.htm http://www.umabrothers.in/latanoprost.htm Fri, 10 Jan 2020 00:00:00 +0530 Latanoprost is a prostaglandin analog. The chemical classification of latanoprost is prostaglandins.Latanoprost is a prostaglandin f2alpha analogue and a prostanoid selective fp receptor agonist with an ocular hypertensive effect. Latanoprost Increases uveoscleral outflow and thereby reduces intraocular pressure.Latanoprost Is Light Yellow Thick Oil. It Is Soluble In Dmso (25 Mg/Ml), Ethanol (25 Mg/Ml), Acetonitrile, Acetone, Ethyl Acetate, Isopropanol, Methanol, Octanol, And Chloroform Insoluble In Water. Lidocaine http://www.umabrothers.in/lidocaine.htm http://www.umabrothers.in/lidocaine.htm Fri, 10 Jan 2020 00:00:00 +0530 Lidocaine is a local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and it’s effects more prolonged than those of procaine but its duration of action is shorter than that of bupivacaine or prilocaine. Lidocaine is an amide local anesthetic and antiarrhythmic. The physiologic effect of lidocaine is by means of local anesthesia. The chemical classification of lidocaine is amides.Lidocaine is a synthetic aminoethylamide with local anesthetic and antiarrhythmic properties. Lidocaine stabilizes the neuronal membrane by binding to and inhibiting voltage-gatedsodium channels, thereby inhibiting the ionic fluxes required for the initiation and conduction of impulses and effecting local anesthesia.Lidocaine is a white or slightly yellow, crystalline powder. It is very soluble in alcohol, chloroform; freely soluble in ether, benzene dissolves in oils with melting range of 66°c to 69°c. Moxifloxacin Hydrochloride http://www.umabrothers.in/moxifloxacin-hydrochloride.htm http://www.umabrothers.in/moxifloxacin-hydrochloride.htm Fri, 10 Jan 2020 00:00:00 +0530 Moxifloxacin Hydrochloride Is The Hydrochloride Salt Preparation Of Moxifloxacin, An 8-Methoxy-Fluoroquinone Compound With Broad-Spectrum Bactericidal Activity Against Gram-Positive & Gram-Negative Strains. 8-Methoxy-Fluoroquinones Are Described To Inhibit The Activities Of Topo Ii (DNA Gyrase) & Topoisomerase Iv. The 8-Methoxy Group Of Moxifloxacin Is Suggested To Confer A Lowered Propensity For Resistance Development As Compared To Other C-8 Substituted Quinolones, & Moxifloxacin Demonstrates Potent Activity Against Wild-Type And First-Step Gyrase- & Topoisomerase Iv-Resistant Mutants. Moxifloxacin Shows Activity Against Methicillin-Susceptible Staphy Lococci, Penicillin-Susceptible And Penicillin-Resistant Pneumococci, Penicillin-Susceptible & Penicillin-Resistant Viridans Group streptococci, Group A streptococci, m. Catarrhalis, & H. Influenzae in Vitro.Synonyms : 7-[(4as,7as)-1,2,3,4,4a,5,7,7a-Octahydropyrrolo[3,4-B]Pyridin-6-Yl]-1-Cyclopropyl-6-Fluoro-8-Methoxy-4-Oxoquinoline-3-Carboxylic Acid;Hydrochloride.Moxifloxacin Hydrochloride is a Slightly Yellow to Yellow Crystalline Substance. It is Sparingly Soluble in Water (24 Mg/ml), Dmso (88 Mg/ml At 25 °c), and Ethanol (<1 Mg/ml At 25 °c) with Melting Ran. Ornidazole http://www.umabrothers.in/ornidazole.htm http://www.umabrothers.in/ornidazole.htm Tue, 14 Jan 2020 00:00:00 +0530 Ornidazole Is A Nitroimidazole Antiprotozoal Agent Used In Ameba And Trichomonas Infections. It Is Partially Plasma-Bound And Also Has Radiation-Sensitizing Action. Ornidazole Is An Anti-Infective; Used To Treat Selected Protozoan Infections. It Has Been Investigated For Use In Crohn's Disease After Bowel Resection.Ornidazole is crystalline solid powder. It is soluble in chloroform and methanol with melting range of 85°c to 90°c. Quetiapine http://www.umabrothers.in/quetiapine.htm http://www.umabrothers.in/quetiapine.htm Fri, 10 Jan 2020 00:00:00 +0530 Quetiapine is a dibenzothiazepine and antipsychotic agent that targets the serotonin 5-ht2 receptor; histamine h1 receptor, adrenergic alpha1 and alpha2 receptors, as well as the dopamine d1 receptor and dopamine d2 receptor. It is used in the treatment of schizophrenia; bipolar disorder & depressive disorder. Quetiapine is an atypical antipsychotic.Quetiapine is a dibenzothiazepine derivative with antipsychotic property. Quetiapine fumarate antagonizes serotonin activity mediated by 5-ht 1a and 5-ht2 receptors. With a lower affinity, this agent also reversibly binds to dopamine d1 and d2 receptors in the mesolimbic and mesocortical areas of the brain leading to decreased psychotic effects, such as hallucinations and delusions. In addition, quetiapine also binds to other alpha-1, alpha-2 adrenergic and histamine h1 receptors.Quetiapine Is White Solid Powder. It Is Soluble In Dmso, And Water With Melting Point Of 223.40°C. Rizatriptan http://www.umabrothers.in/rizatriptan.htm http://www.umabrothers.in/rizatriptan.htm Fri, 10 Jan 2020 00:00:00 +0530 Rizatriptan is a serotonin-1b and serotonin-1d receptor agonist. The mechanism of action of rizatriptan is as a serotonin 1b receptor agonist and serotonin 1d receptor agonist. Rizatriptan is a triptan drug used for the treatment of migraine headaches. It is a selective 5-hydroxy tryptamine1 receptor subtype agonist.Rizatriptan Is A White Powder. It Is Soluble In Water With Melting Range Of 178°C TP 180°C. Sumatriptan http://www.umabrothers.in/sumatriptan.htm http://www.umabrothers.in/sumatriptan.htm Fri, 10 Jan 2020 00:00:00 +0530 Sumatriptan Is A Serotonin Agonist That Acts Selectively At 5ht1 Receptors. It Is Used In The Treatment Of Migraine Disorders. Sumatriptan Is A Serotonin-1b And Serotonin-1d Receptor Agonist. The Mechanism Of Action Of Sumatriptan Is As A Serotonin 1b Receptor Agonist & Serotonin 1d Receptor Agonist.Sumatriptan Is A Sulfonamide Triptan With Vasoconstrictor Activity. Sumatriptan Selectively Binds To & Activates Serotonin 5-Ht1d Receptors In The Central Nervous System (CNS), Thereby Constricting Cerebral Blood Vessels. This May Lead To A Relief In Pain From Vascular Headaches. Sumatriptan May Also Relieve Vascular Headaches By Decreasing The Release Of Vasoactive Neuropeptides From Perivascular Trigeminal Axons In The Dura Mater During A Migraine, By Reducing Extravasation Of Plasma Proteins, And By Decreasing The Release Of Other Mediators Of Inflammation From The Trigeminal Nerve.Sumatriptan Is A White Crystalline Solid Or Powder. It Is Soluble In water, 2.14x10+4 Mg/L At 25 Deg C (EST) With Melting Range Of 169°C TO 171°C. Tacrolimus http://www.umabrothers.in/tacrolimus.htm http://www.umabrothers.in/tacrolimus.htm Fri, 10 Jan 2020 00:00:00 +0530 Tacrolimus is a macrolide isolated from the culture broth of a strain of streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of t-lymphocytes in response to antigenic or mitogenic stimulation in vitro. Tacrolimus anhydrous is a calcineurin inhibitor immunosuppressant. The mechanism of action of tacrolimus anhydrous is as a calcineurin inhibitor.Anhydrous from of tacrolimus, a macrolide isolated from streptomyces tsukubaensis. Tacrolimus binds to the fkbp-12 protein and forms a complex with calcium-dependent proteins, thereby inhibiting calcineurin phosphatase activity and resulting in decreased cytokine production. This agent exhibits potent immunosuppressive activity in vivo & prevents the activation of t-lymphocytes in response to antigenic or mitogenic stimulation. Tacrolimus possesses similar immunosuppressive properties to cyclosporine, but is more potent.Tacrolimus Is A White Crystalline Solid Powder. It Is Soluble In Chloroform And Methanol With Melting Range Of 90°C TO 92°C. Microcrystalline Cellulose Powder http://www.umabrothers.in/microcrystalline-cellulose-powder.htm http://www.umabrothers.in/microcrystalline-cellulose-powder.htm Fri, 10 Jan 2020 00:00:00 +0530 Microcrystalline cellulose is a term for refined wood pulp and is used as a texturizer, an anti-caking agent, a fat substitute, an emulsifier, an extender, and a bulking agent infood production.[1]The most common form is used in vitamin supplements or tablets. It is also used in plaque assays for counting viruses, as an alternative tocarboxymethylcellulose.[2]Microcrystalline cellulose (c6h10o5)n is refined wood pulp. It is a white, free-flowing powder. Chemically, it is an inert substance, is not degraded during digestion and has no appreciable absorption. In large quantities it provides dietary bulk and may lead to a laxative effect.Microcrystalline cellulose is a commonly used excipient in the pharmaceutical industry. It has excellent compressibility properties and is used in solid dose forms, such as tablets. Tablets can be formed that are hard, but dissolve quickly. Microcrystalline cellulose is the same as cellulose, except that it meets bp/usp/ep standards. Silver Sulfadiazine http://www.umabrothers.in/silver-sulfadiazine.htm http://www.umabrothers.in/silver-sulfadiazine.htm Fri, 10 Jan 2020 00:00:00 +0530 Silver sulfadiazine is a sulfonamide antibacterial. The chemical classification of silver sulfadiazine is sulfonamides. Sulfadiazine silver is a sulfonamide-based topical agent with antibacterial & antifungal activity. silver sulfadiazine may act through a combination of the activity of silver & sulfadiazine. When this agent interacts with sodium chloride-containing body fluids, silver ions are released slowly and sustainably into wounded areas. Ionized silver atoms catalyze the formation of disulfide bonds leading to protein structural changes and inactivating thiol-containing enzymes; silver ions may also intercalate dna thereby interfering with replication and transcription of bacteria. As a competitive inhibitor of para-aminobenzoic acid (paba),  sulfadiazine inhibits bacterial dihydropteroate synthase, thereby resulting in disruption of folic acid metabolism and ultimately dna synthesis.Silver sulfadiazine is a crystalline solid. It is soluble in water with melting range of 282°C t0 284°C. Phenoxyethanol http://www.umabrothers.in/phenoxyethanol.htm http://www.umabrothers.in/phenoxyethanol.htm Fri, 10 Jan 2020 00:00:00 +0530 Phenoxyethanol is chemical preservative, a glycol ether often used in dermatological products such as skin creams andsunscreen. It is a colorless oily liquid. It is a bactericide (usually used in conjunction with quaternary ammonium compounds), often used in place of sodium azide in biological buffers because phenoxyethanol is less toxic and non-reactive with copper an lead. It is used in many applications such as cosmetics, vaccines and pharmaceuticals as a preservative.It is also used as a fixative for perfumes, an insect repellent, a topical antiseptic, a solvent for cellulose acetate, some dyes, nks, and resins, in preservatives, pharmaceuticals, and in organic synthesis. It is moderately soluble in water. It is used as an anestheticin the aquaculture of some fish.[1][2]It is also listed as an ingredient for many united states vaccines by the center for disease control.[3] in japan and the eu, its usage level in cosmetic products is restricted to concentrations of up to 1%.[4][5]We are supplying this product in 200 kilos export worthy barrels and one 20 feet container can carry 80 barrels. Our material can be used in cosmetics & pharmaceuticals as phenol content is less than 5 ppm Pharmaceutical Intermediates http://www.umabrothers.in/pharmaceutical-intermediates.htm http://www.umabrothers.in/pharmaceutical-intermediates.htm Tue, 14 Jan 2020 00:00:00 +0530 Details 3-amino-4-methylamino-benzoic acid-n-(2-pyridyl)-n-(2- ethoxycarbonylethyl)-amide (212322-56-0) N-(4-cynophenyl)-glycine (42288-26-6) Ethyl 3-(2-((4-cyanophenylamino) methyl)-1-methyl-n- (pyridine-2-yl)-1h-benzo[d]imidazole-5- carboxamido) propanoate (211915-84-3) 2-(n-boc)-aminothiazole-5-carboxylic acid (302964-02-9) 2-amino-n-(2-chloro-6-methylphenyl)thiazole-5-carboxamide (302964-24-5) N-(2-chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl) amino]-5- thiazole carboxamide (302964-08-5) 4,6-dichloro-2-methylpyrimidine (1780-26-3) 3-(n-methyl-n-pentyl amino) propionic acid hcl (625120-81-2) Etyl 2-(2-aminothiazol-4-yl) acetate (53266-94-7) 2-amino-4-thiazole acetic acid (29676-71-9) 2-amino-4-thiazole acetic acid hydrochloride (521284-21-9) 2-(4-nitrophenyl) ethanamine hydrochloride (29968-78-3) (r)-2-(4-nitrophenethylamino)-1-phenylethanol hydrochloride (521284-21-9) (r)-2-(4-aminophenethylamino)-1-phenylethanol hcl (521284-22-0) [2-(4-aminophenyl) ethyl] carbamic acid tert-butyl ester (94838-59-2) (r)-4-nitro phenethylamino-(2- hydroxy-2-phenylethyl)-tert-butyl carbamate (223673-35-6) 1,2,3,9-tetrahydro-9-methyl-4(h)-carbazol-4-one (27387-31-1) 3-[(dimethylamino) methyl]-1,2,3,9-tetrahydro-9-methyl-4hcarbazol- 4-one hcl (119812-29-2) 11-(piperazine-1-yl)dienzo[b,f][1,4]thiazepine hydrochloride (11974-74-4) 3-quinuclidinone hydrochloride (1193-65-3) (3ar,4s,6r,6as)-6-aminotetrahydro-2,2-dimethyl-4h-cyclopenta-1,3-dioxol-4-ol(cas 155899-66-4) Poly Ethylene Glycol http://www.umabrothers.in/poly-ethylene-glycol.htm http://www.umabrothers.in/poly-ethylene-glycol.htm Fri, 10 Jan 2020 00:00:00 +0530 Poly ethylene glycol series consist of peg 400, peg 1500, peg 3350, peg 4000, peg 6000 etc. We are offering best quality materials which is accepted by leading consumers worldwide. Polyethylene glycol is a polyether compound with many applications from industrial manufacturing to medicine. The structure of peg is also known as polyethylene oxide or polyoxyethylene, depending on its molecular weight. Peg 400 (cas no.25322-68-3) is in liquid form complies with bp/usp standards and used in industries like pharmaceutical, oil exploration, ink, rubber, paper, textile etc. Peg 1500 (cas no.25322-68-3) is in liquid form complies with bp/usp standards and used in industries like pharmaceutical, oil exploration, ink, rubber, paper, textile etc.;' Peg 3350 (cas no.25322-68-3) is in powder/flakes form complies with bp/usp standards and used in industries like pharmaceutical, cosmetics, oinments rubber, paper, textile Peg 4000 (cas no.25322-68-3) is in powder/flakes form complies with bp/usp standards and used in industries like pharmaceutical, cosmetics, oinments rubber, paper, textile Peg 6000 (cas no.25322-68-3) is in powder/flakes form complies with bp/usp standards and used in industries like pharmaceutical, cosmetics, oinments rubber, paper, textile Peg 8000 (cas no.25322-68-3) is in powder/flakes form complies with bp/usp standards and used in industries like pharmaceutical, cosmetics, oinments rubber, paper, textile On specific requirements, we can also offer peg 200, peg 300, peg 600 etc. Available in export worthy packing of 25 kg bag/drum, 50kg carboys, 230 kg hdpe drums or as per our customer requirements Tafluprost http://www.umabrothers.in/tafluprost.htm http://www.umabrothers.in/tafluprost.htm Fri, 10 Jan 2020 00:00:00 +0530 Tafluprost is a prostaglandin analogue. This molecule is used topically for controll of advancing open-angle glaucoma and related problems. It is also used for ocular hypertension, alone or in combination with other molecules. It reduces intraocular pressure by increasing the outflow of aqueous fluid from the eyes.Chemically, tafluprost is a fluorinated analog of prostaglandin f2-alpha. This chemical compound belongs to the class of organic compounds known as prostaglandins and related compounds. Tafluprost is light yellow to yellow viscous oil with purity more than 99% by hplc. It is freely soluble in ethanol with melting range of 87.5°c. It is practically insoluble in water. Travoprost http://www.umabrothers.in/travoprost.htm http://www.umabrothers.in/travoprost.htm Fri, 10 Jan 2020 00:00:00 +0530 Travoprost Used To Treat High Pressure Inside The Eye Including Glaucoma. Specifically It Is Used For Open Angle Glaucoma When Other Agents Are Not Sufficient. This Eye Drops Generates Effect Within 2 Hours.Travoprost Ophthalmic Solution Is Used For Controlling Progression Of Glaucoma Or Ocular Hypertension, By Reducing Intraocular Pressure Label. It Is A Synthetic Prostaglandin F2alpha Analog.Synonyms: (((1r)-(1alpha (z), 2 beta (1e,3r*),3alpha,5alpha))-7-(3,5-dihydroxy-2-(3-hydroxy-4-(3-trifluoromethyl)phenoxy)-1-butenyl)cyclopentyl)-5-heptenoic acid, 1-methylethyl esterTravoprost is clear colourless viscous oil with purity more than 99% by hplc and specific optical rotation +53.5 degrees. It is practically insoluble in water. API Pellets http://www.umabrothers.in/api-pellets.htm http://www.umabrothers.in/api-pellets.htm Fri, 10 Jan 2020 00:00:00 +0530 We are offering pharmaceutical grade pellets and granules.Basically, pellets are offered as api or substance with excipients in form of spherical or semi-spherical fine particles with free flowing nature. Pellets offers more features compared with conventional tablets.When api or substance solid powder converted in grains or granules by granulation process, product is called granules. Granules are more effective than conventional tablets.Pellets Aceclofenac sr pellets 50%/60%   Ambroxol hcl er/sr pellets 24%/25% & 45% Aprepitant pellets 40%   Azithromycin ir 40%/taste mask pellets 7% Cetirizine hcl ir 10%   Chlorpheniramine maleate er pellets 10% Clarithromycin taste mask pellets 7.5% Dabifatran pellets 40% to 60 % Diltiazem hcl er pellets 37% to 80%   Domperidone ir & sr pellets 10% to 40%  Duloxetine hcl dr pellets 10% to 25%   Dutasteride ir pellets 0.5 % Erythromycin ec 50%   Esomeprazole dr pellets 7.5% to 26.67%   Fenofibrate ir & sr pellets 60% & 66%   Finasteride ir 6.5% Fluconazole ir 41.6%   Flunarizine ir 5%, 10% Glimepiride ir 1%   Ibuprofen ir pellets 70% Isosorbide mononitrate ir 10%   Itopride hcl sr 50%/60% & 70% Itraconazole ir pellets 20% to 44%   Ketoprofen er pellets 40%/65%/70% & 80% Lansoprazole ec pellets 6.5% to 15%   Levocetirizine hcl ir pellets 6.5% Levosulpiride sr 40% & 50%   Mebeverine er pellets 50%/60%/70% & 80% Memantine sr pellets 16%   Metoprolol succinate sr pellets 61%/66% Paracetamol ir pellets 80%/ Taste mask pellets 20.58% & 50% Paroxetine hcl sr 21%   Phenylephrine hcl er pellets 20% & 40% Pregabalin ir pellets 50%/54%/60%90%   Propanolol er pellets 7.5%/8.5%/10% Salbutamol sulphate sr 8%   Secnidazole ir 50% Sildenafil citrate ir pellets 5% to 20%   Tacrolimus micro pellets 5%/1% & 0.5% Tizanidine sr pellets 3.5%   Tolterodine tartarate sr pellets 22% Omeprazole ec pellets 7%/8.5%/10%/11%/15%/20%/22.5%/25%/30% Orlistat ir pellets 17%/20%/25%/40%/50% & 60% Pantoprazole ec pellets 8.5%/15%/20%/22.5% & 30% Rabeprazole sodium ec pellets 8.5%/11.2%/13.33%/15% & 20% Tamsulosin hcl sr pellets 0.12%/0.13%/0.16%/0.2%,0.33% & 0.4% Venlafaxine hcl sr pellets 14%/23%/28%/32%/33%/39%/40%/47% & 50% Granules Azithromycin 65.27% Dc Granules For Tablets/7.5% Tm Granules For Suspension Ciprofloxacin 20% Tm Granules For Suspension/65%/75% Dc Granules For Tablets Clarithromycin 42% Granules Suspension/Tablets/62.5% Dc Granules For Tablets Clarithromycin 7.5% & 27.5% Tm Granules For Suspension Clarithromycin Granules (TASTE Masking) 27.5%, 30%, 33%, 42% (SUSPENSION Grade) Ibuprofen 67% Pre-Mix Granules For Suspension/90% Dc Granules For Tablets Lansoprazole Granules (CAPSULE/TABLET Dc Granules) Metformin Hcl 66.66%/70% Sr Granules For Tablets/90%/95% Dc Granules Tablets Paracetamol 12% Pre-Mix Granules For Suspension/65%/90% Dc Granules Tablets Tadalafil Dc Granules 8 % W/W Usp Empagliflozin http://www.umabrothers.in/empagliflozin.htm http://www.umabrothers.in/empagliflozin.htm Fri, 10 Jan 2020 00:00:00 +0530 Empagliflozin is new molecule to fight type 2 diabetes. It is good inhibitor of sodium-glucose co-transporter 2 (sglt2; slc5a2) with antihyper glycemic activity. It improves glycemic control in adults with type 2 diabetes mellitus. It is formulated as coated tablets and film-coated tablets for oral route of administration.Empagliflozin is a sodium-dependent glucose transporter-2 inhibitor (sglt-2 inhibitor). The drug candidate leads to reductions in hepatic glucose production and amelioration of glucotoxicity.It Is White Colour Powder With Purity More Than 99% And Have Boiling Point 665 C Degree And Flash Point Is 356 C Degree. Prilocaine http://www.umabrothers.in/prilocaine.htm http://www.umabrothers.in/prilocaine.htm Tue, 14 Jan 2020 00:00:00 +0530 Prilocaine is a local anesthetic of the amino amide type. It is often used in dentistry. It is also often combined with lidocaine as topical preparation for dermal anesthesia, for treatment of conditions like paresthesia.It works by blocking nerve signals in the body and used as local anesthetics. This is also used for smaller surgery.Prilocaine binds to the intracellular surface of sodium channels which blocks the subsequent influx of sodium into the cell. This block is reversible and when the drug diffuses away from the cell, sodium channel function is restored and nerve propagation returns.Prilocaine acts on sodium channels on the neuronal cell membrane, limiting the spread of seizure activity and reducing seizure propagation.The antiarrhythmic actions are mediated through effects on sodium channels in purkinje fibers.It Is White Crystalline Powder With Purity More Than 99% And Insoluble In Water And Very Soluble In Acetone & Ethanol (96%). Sevelamer Carbonate http://www.umabrothers.in/sevelamer-carbonate.htm http://www.umabrothers.in/sevelamer-carbonate.htm Fri, 10 Jan 2020 00:00:00 +0530 Sevelamer Is A Phosphate Binding Drug Used To Treat Hyperphosphatemia In Patients With Chronic Kidney Disease. When Taken With Meals, It Binds To Dietary Phosphate And Prevents Its Absorption.Sevelamer Is Used To Lower High Blood Phosphorus (PHOSPHATE) Levels In Body Kept On Dialysis. Dialysis Removes Some Phosphate From Blood, But It Is Difficult To Remove Enough To Keep Phosphate Levels Balanced. By Decreasing Blood Phosphate Levels, It Helps To Keep Bones Strong, Prevent Unsafe Buildup Of Minerals In The Body. This Actions Decrease The Risk Of Heart Disease/Strokes. Sevelamer Works By Holding Onto Phosphate From The Diet So That It Can Pass Out Of The Body.Sevelamer Carbonate Is Off White To Pale Yellow Powder With Carbonate Content 28% To 40% Limit, Residue On Ignition Nmt 0.5% & Loss On Drying Nmt 6%. This Is Offered As In House Specifications.Sevelamer Hydrochloride Is Pale Yellow Colour Powder With Melting Point Is More Than 240 C Degree. Vardenafil HCL Trihydrate http://www.umabrothers.in/vardenafil-hcl-trihydrate.htm http://www.umabrothers.in/vardenafil-hcl-trihydrate.htm Tue, 14 Jan 2020 00:00:00 +0530 Vardenafil hydrochloride trihydrate is the hydrochloride salt form of vardenafil, a benzenesulfonamide derivative and phosphodiesterase type 5 (pde5) inhibitor with vasodilatory activity.Vardenafil is an oral therapy for the treatment of erectile dysfunction. It is a selective inhibitor of cyclic guanosine monophosphate - specific phosphodiesterase type 5 (pde5). During stimulation, nitric oxide is released from nerve endings and endothelial cells in the corpus cavernosum. Nitric oxide activates the enzyme guanylate cyclase resulting in increased synthesis of cyclic guanosine monophosphate (cgmp) in the smooth muscle cells of the corpus cavernosum. The cgmp in turn triggers smooth muscle relaxation, allowing increased blood flow. Therefore, the inhibition of pde5 enhances erectile function by increasing the amount of cgmp.Iupac name : 2-{2-ethoxy-5-[(4-ethylpiperazin-1-yl)sulfonyl] phenyl}-5-methyl-7-propyl-1h,4h-imidazo[4,3-f][1,2,4]triazin-4-one trihydrate hydrochlorideVardenafil hydrochloride trihydrate is white powder with assay more than 99% by hplc (anhydrous substance). It is slightly solube in water, freely soluble in anhydrous ethanol & practicaly insoluble in heptane. Glycerophosphate http://www.umabrothers.in/glycerophosphate.htm http://www.umabrothers.in/glycerophosphate.htm Fri, 10 Jan 2020 00:00:00 +0530 Calcium Glycerophosphate: CAS nO. 27214 – 00 – 2MF: C3H7CA06P Einecs no. 248-328-5Purity: 98% MIN Specification : White powder, odorless, tasteless, Assay on dry basis: 99.46%, Glycerophosphate: 8.6 ml, Residue on ignition: 52.52% Application: Nutritional supplements food calcium fortifier, stabilizer, for baby food, bread, baking powder, flour, noodles etc, for the preparation of compound, in pharmaceutical formulationsSodium Glycerophosphate: Case no. 154804-51-0Other names: Glycerol phosphate disodium salt Type - electrolyte balance and dialysis agentsSpecification : White Colour Crystal PowderApplication : In Food Industry, It Is Also Used As Buffer, Chelate Agent Nutrient Additive, Emulsifier, Flavour For Yoghurt Etc, Nutrition DrugPotassium Glycerophosphate : Pale Yellow Liquid Of 50% & 75%  Chemical Formula: C3H7K206P 3H20Molecular Weight: 302.30Application : Potassium Plays A Key Role In The Function Of Nerve Firing & Muscular Contraction. It Helps Reduce Muscle Soreness & Deficiency May Result In Decreased Strength And The Early Onset Of Exercise Induced Fatigue. It Helps To Regulate Water Balance And Is Also Needed For The Synthesis Of Dietary Proteins. Potassium Glycerophosphate Is One Of The Most Absorbable And Bioavailable Forms Of Potassium Available. In The Glycerophosphate Form, The Potassium Is Highly Soluble In Water.Magnesium Glycerophate: White PowderChemical Formula : MG3 (PO4)2, Molecular Weight: 262.98Application : Used As Food Additives, Nutrition Supplement Agent, Atilithic, Precipitor, Sanding Agent Etc.Magnesium Is Needed For More Than 300 Biochemical Reactions In The Body Including Maintaining Normal Muscle & Nerve Function, Involved In Energy Metabolism & Protein Synthesis, Supplementation Is Deemed Necessary For Anybody Training DailyManganese Glycerophosphate : White PowderApplication : Used To Prevent Weak Bones, To Fight Anemia And As A Mneral Supplement Of ManganeseCalcium Glycerophosphate, Sodium Glycerophosphate, Potassium Glycerophosphate, Magnesium Glycerophosphate, Manganese Glycerophosphate, Ferric Glycerophosphate Supplied By Uma Brothers