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Uma Brothers

Ketorolac Tromethamine

Ketorolac Tromethamine

Product Details

Synonyms 2-amino-2-(hydroxymethyl) propane-1, 3-DIOL; 5-benzoyl-2, 3-dihydro-1H-pyrrolizine-1-carboxylic acid
CAS Number 74103-07-4
MOL. Formula C19H24N2O6
MOL.Weight 376.4
Standard Offered of Pharmaceutical Grade BP/USP/EP
Packing Offered in Export Worthy Packing of 25 Kilos or as per Our Customer Requirements
Supplied By UMA Brothers, India

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Ketorolac Tromethamine Is A Pyrrolizine Carboxylic Acid Derivative Structurally Related To Indomethacin. It Is A Non-Steroidal Anti-Inflammatory Agent Used For Analgesia For Postoperative Pain And Inhibits Cyclooxygenase Activity.

Ketorolac Tromethamine is The tromethamine salt Of ketorolac, A Synthetic Pyrrolizine Carboxylic Acid derivative With Anti-Inflammatory, Analgesic & Antipyretic Properties.Ketorolac Tromethamine, A Non-Selective Inhibitor Of The Cyclooxygenases (COX), Inhibits Both Cox-1 & Cox-2 Enzymes. This Agent Exerts Its Anti-Inflammatory Effect By Preventing Conversion Of arachidonic Acid to Prostaglandins At Inflammation Site Mediated Through Inhibition Of Cox-2, Which Is Undetec- Table In Most Tissues But Is Up-Regulated At The Inflammation Sites. Since Cox-1 Is Expressed Virtually In All Tissues, Inhibition Of Cox-1 Enzyme By This Agent Prevents Normal State Production Of Prostaglandins, Which Plays Housekeeping Roles In The Protection Of The Gastrointestinal Tract, Regulating Renal Blood Flow, And Functioning In Platelet Aggregation. As A Result, Inhibition Of Cox-1 Is Usually Associated With Adverse Effects Such As Gastrointestinal Toxicity And Nephrotoxicity.

Ketorolac Tromethamine is Off-white to Pale Yellow Solid. It is Soluble in Ethanol (~7 Mg/ml), Dmf (~50 Mg/ml), Dmso (~7 Mg/ml), Water (15 Mg/ml), and Methanol with Melting Range of 160°C to 162°C.

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