Uma Brothers

Vardenafil HCL Trihydrate

Business Type Exporter, Supplier
CAS No. 330808-88-3
Purity 98%
Supplied By UMA Brothers, India
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Vardenafil hydrochloride trihydrate is the hydrochloride salt form of vardenafil, a benzenesulfonamide derivative and phosphodiesterase type 5 (pde5) inhibitor with vasodilatory activity.

Vardenafil is an oral therapy for the treatment of erectile dysfunction. It is a selective inhibitor of cyclic guanosine monophosphate - specific phosphodiesterase type 5 (pde5). During stimulation, nitric oxide is released from nerve endings and endothelial cells in the corpus cavernosum. Nitric oxide activates the enzyme guanylate cyclase resulting in increased synthesis of cyclic guanosine monophosphate (cgmp) in the smooth muscle cells of the corpus cavernosum. The cgmp in turn triggers smooth muscle relaxation, allowing increased blood flow. Therefore, the inhibition of pde5 enhances erectile function by increasing the amount of cgmp.

Iupac name : 2-{2-ethoxy-5-[(4-ethylpiperazin-1-yl)sulfonyl] phenyl}-5-methyl-7-propyl-1h,4h-imidazo[4,3-f][1,2,4]triazin-4-one trihydrate hydrochloride

Vardenafil hydrochloride trihydrate is white powder with assay more than 99% by hplc (anhydrous substance). It is slightly solube in water, freely soluble in anhydrous ethanol & practicaly insoluble in heptane.

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