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Silver sulfadiazine is a sulfonamide antibacterial. The chemical classification of silver sulfadiazine is sulfonamides. Sulfadiazine silver is a sulfonamide-based topical agent with antibacterial & antifungal activity. silver sulfadiazine may act through a combination of the activity of silver & sulfadiazine. When this agent interacts with sodium chloride-containing body fluids, silver ions are released slowly and sustainably into wounded areas. Ionized silver atoms catalyze the formation of disulfide bonds leading to protein structural changes and inactivating thiol-containing enzymes; silver ions may also intercalate dna thereby interfering with replication and transcription of bacteria. As a competitive inhibitor of para-aminobenzoic acid (paba), sulfadiazine inhibits bacterial dihydropteroate synthase, thereby resulting in disruption of folic acid metabolism and ultimately dna synthesis.
Silver sulfadiazine is a crystalline solid. It is soluble in water with melting range of 282°C t0 284°C.