Uma Brothers


Business Type Exporter, Supplier
Synonyms 16-dimethoxy-4, 10, 12, 18-tetramethyl-8-3-(2-(4-hydroxy-3-methoxycyclohexyl)-1;
Cas Number 104987-11-3
Mol. Formula C44H69NO12
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Offered of Pharmaceutical Grade BP/USP/EP
Offered in Export Worthy Packing of 25 Kilos or as per Our Customer Requirements
Supplied By
UMA Brothers, India

Tacrolimus is a macrolide isolated from the culture broth of a strain of streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of t-lymphocytes in response to antigenic or mitogenic stimulation in vitro. Tacrolimus anhydrous is a calcineurin inhibitor immunosuppressant. The mechanism of action of tacrolimus anhydrous is as a calcineurin inhibitor.

Anhydrous from of tacrolimus, a macrolide isolated from streptomyces tsukubaensis. Tacrolimus binds to the fkbp-12 protein and forms a complex with calcium-dependent proteins, thereby inhibiting calcineurin phosphatase activity and resulting in decreased cytokine production. This agent exhibits potent immunosuppressive activity in vivo & prevents the activation of t-lymphocytes in response to antigenic or mitogenic stimulation. Tacrolimus possesses similar immunosuppressive properties to cyclosporine, but is more potent.

Tacrolimus Is A White Crystalline Solid Powder. It Is Soluble In Chloroform And Methanol With Melting Range Of 90°C TO 92°C.

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